The effect of auxiliary substances on pharmaceutical availability of medicinal substances contained in dry extract from small-flowered willow herb (Epilobium parviflorum Schreb.)

Z. MARCZYŃSKI, M. ZGODA

Abstract

Therapeutic agents of natural origin, administered in prostatic disorders, have wider experimental and clinical documentation than the synthetic medicines, fashionable, but relatively new on the market. Their superiority is based first of all on versatile points of effect, almost total lack of side efifects and a significantly low cost of therapy. Bearing in mind the above mentioned, an attempt was made to produce an oral solid form of a drug from dry aqueous extract of small-flowered willow herbs (E. parviflorum), using some formulating components of variable adsorptive properties. Taking into account the composition and granulometric properties of the extract, two alternative technological processes have been suggested to produce oral solid model pharmaceutical agents. These model forms were subjected to the following morphological tests determining: the appearance of tablets, their mass, friability and efiective disintegration time. Furthermore, pharmaceutical availability of the model form of the drug was investigated. The effect of formulating components on the course of quantitative determination of active agents was assessed in the tablets.
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