Molecular mechanisms of cancer-preventive effects of garlic organosulfur compounds
Pharmacological activity of garlic (Allium sativum L.) has been thoroughly evaluated for many years. The development of modern techniques in phytochemical analysis has enabled to detect a broad spectrum of organosulfur compounds which have an interesting biological activity. Recently, inhibition of carcinogenesis, observed at many stages, has seemed to be the most important feature. It has been established that garlic organosulfur compounds can inhibit cancer development through multiple mechanisms, including mostly: modulating activity of carcinogen-metabolising enzymes, direct antiradical activity, inhibiting cell proliferation and promoting apoptosis.