The antimicrobial activity of Prunella vulgaris extracts
Abstract
Prunella vulgaris ( Labiatae family) or self-heal is traditionally used for different ailments
such as eye pain and inflammation, headache, dizziness, sore throat and wound healing.
Total phenolic and total flavonoid contents of extracts (methanol, ethanol and aqueous)
were determined by a spectrophotometer. The antimicrobial activity was evaluated by
micro broth dilution assay. The total phenolic content of P. vulgaris extracts were higher
in aqueous extract (156.5 mg GAC/g) followed by ethanol extract and methanol extract.
The TFC content of P. vulgaris methanol extract (82.8 mg QE/g) was higher than ethanol
extract (22.7 mg QE/g) and aqueous extract (16.2 mg QE/g). The antimicrobial activity of
methanol or ethanol extracts was higher than aqueous extract from P. vulgaris. The sensitivity
of microorganisms to different extracts is related to type of pathogens. There is
no positive relation between total phenolic content and its antimicrobial activity. Prunella
vulgaris ethanolic extract as a source of phenolic and flavonoid contents can be used as an
antimicrobial agent.