Effect of ethanol extract of Graptophyllum pictum (L.) Griff. on cisplatin induced nephrotoxicity in rats
Abstract
The purpose of the present study is to investigate whether the alcoholic extract of Graptophyllum
pictum (L.) Griff. could decrease the intensity of nephrotoxicity in albino rats.
Cisplatin at a single dose of 12 mg/kg body weight was administered intraperitonially to
albino male Wistar rats. Nephrotoxicity was assessed by determining the serum creatinine
and urea levels as well as renal antioxidant status in rats after cisplatin administration.
Ethanolic extract of G. pictum at 150 and 300 mg/kg body weight was administered orally
after cisplatin injection for 15 days. The extracts could significantly reduce the elevated
serum creatinine and urea levels. Renal antioxidant defence systems, such as superoxide
dismutase, catalase, glutathione peroxidase activities and reduced glutathione level, depleted
by cisplatin therapy were restored to normal by treatment with the extract. Cisplatin
induced lipid peroxidation was also found markedly reduced by treatment with
the extract. This result indicated that ethanolic extract of G. pictum rendered significant
preventive effect against cisplatin induced nephrotoxicity.