The effects of plant extracts of Medicago sativa and Trigonella foenum-graecum on postprandial glucose levels in type 2 diabetic rats

HANNA WINIARSKA, MARZENA DWORACKA, MAŁGORZATA BOROWSKA, TERESA BOBKIEWICZ-KOZŁOWSKA, PIOTR GORECKI, ALINA MŚCISZ, PRZEMYSŁAW M. MROZIKIEWICZ

Abstract

The main purpose of this study was to determine if fenugreek (Trigonella foenum graecum L.) seeds extract (FSE ) and lucerne (Medicago sativa L.) extract (LDE) modulate post-challenge carbohydrate metabolism in type 2 diabetes animal model. Type 2 diabetes was induced in the Wistar rat neonates by intraperitoneal administration of streptozotocin. Experimental animals (60) were divided into following groups: normal rats treated with FSE or LDE, diabetic rats treated with FSE or LDE or glibenclamide or vehicle and given orally examined substances for 4 weeks. Glycaemia was controlled prior to the administration of test substances and at time points of 2 h and 4 h, thereafter at 1st, 7th and the last day of experiment. Insulin serum concentration was measured at time 0 at the same days. The present study demonstrates the ability of FSE and LDE to decrease postprandial glycaemia in type 2 diabetic and non-diabetic rats. It seems that this effect mediated by enhancing insulin secretion is related only for LDE-treatment and observed only in n5-STZ rats.
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