Influence of combined botanical extract preparation on blood lipids, glucose metabolism, leptin and homocysteine. Results from double-blind randomized clinical trial

ŁUCJA PILACZYŃSKA-SZCZĘŚNIAK, PAWEŁ RZYMSKI, IVO PISCHEL

Abstract

Obesity is associated with possible complications like hyperlipidemia, hypertension, coronary heart disease and diabetes. The aim of this study was to evaluate the effect of composite herbal extracts on blood lipids, glucose metabolism, leptin and homocystein. Design: randomised, double-blind, placebo-controlled clinical trial on 51 overweight, healthy subjects. Preparation of nutrifin® support in a form of tablets, which is a botanical water extract composed of green tea extract, bean peels and asparagus was used. Results: changes in lipoprotein, glucose, insulin, leptin and homocysteine failed to produce statistically significant difference. Alteration of lipid profile including: changes of total cholesterol, LDL cholesterol, HDL cholesterol and triglycerides were: –9.4%, –18.7%, +11.8%, –13.4% for nutrifin® support group and –8.0%, –12.2%, +1.4% and 14.8% for placebo group, respectively. Differences between groups were not significant. The change in total cholesterol and LDL cholesterol strongly correlated with start values of total cholesterol and LDL cholesterol. The correlation coefficients were –0.92 and –0.91 (p<0.001) in active extract group, respectively. Conclusions: Most of researched changes in blood parameters in both groups were not significant, but the reduction in total cholesterol and LDL cholesterol was strongly correlated with lipids levels at the start of the study.
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