Cichorin A: a benzo-isochromene from Nypa fruticans endophytic fungus Pestalotiopsis sp.

GIDEON O. ALADE, JONES O. MOODY, OLANREWAJU R. AWOTONA, DAOWAN LAI, SABURI A. ADESANYA, PETER PROKSCH

Abstract

Introduction: Similar bioactive metabolites are obtainable from host plants as well as the endophytic fungi residing in them. Objective: The aim of the study is to isolate the major compound(s) from the endophytic fungus residing in Nypa fruticans Wurmb, Arecaceae family. Methods: Purification of the ethyl acetate extract of the isolated endophytic fungus was performed by employing different chromatographic techniques and structural elucidation of the isolated compound was carried out using UV and NMR spectroscopic methods. Results: Cichorin A was isolated from the ethyl acetate extract of the solid rice cultures of Pestalotiopsis sp., isolated from N. fruticans, collected in Nigeria. Conclusions: This compound is being isolated for the first time from a fungus; it is commonly isolated from the plant Cichorium intybus L. (Compositae).
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