Selected physicochemical and solubilization properties of pharmacopeal solutions of dry green tea leaf extract (Ext. Camellia sinensis L. folium aqu. siccum)

ZBIGNIEW MARCZYŃSKI, BEATA SKIBSKA, SŁAWOMIRA NOWAK, IZABELA RYCHLIŃSKA, JERZY JAMBOR, MARIAN MIKOŁAJ ZGODA

Abstract

Introduction: Green tea offers not only pleasant, delicate flavor, but also provides health benefits. The extract contains, among others, polyphenols responsible for antioxidant and anti-inflammatory properties. They reduce the risk of cancer and their presence exerts preventive activity against cardiovascular diseases. Objective: Analysis of selected physicochemical and solubilizing properties of pharmacopoeial-true solutions of dry green tea extract. Methods: The caffeine content was determined in the extract and in dry residue after solubilization by high performance liquid chromatography. The process of micellar solubilization of cholesterol granules and ketoprofen was carried out in model solutions of green tea extract. Results: The obtained results indicate that the prepared ‘ex tempore’ leaf green tea infusion subjected to short thermal exposure will be characterized by significant solubilization abilities. Conclusions: The outcomes of the research pointed to the possibility of developing a solid oral dosage form with titrated dry green tea extract of expected pharmacotherapeutic profile.
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