Studies on the biological properties of extracts from Centella asiatica (L.) Urban herb

BOGDAN KĘDZIA, TERESA BOBKIEWICZ-KOZŁOWSKA, MIROSŁAWA FURMANOWA, PRZEMYSŁAW MIKOŁAJCZAK, ELŻBIETA HOŁDERNA-KĘDZIA, IRENA OKULICZ-KOZARYN,JOANNA WÓJCIK, JOANNA GUZEWSKA, WALDEMAR BUCHWALD, ALINA MŚCISZ, PRZEMYSŁAW M. MROZIKIEWICZ

Abstract

The aqueous-ethanol extracts (30% ethanol) from Centella asiatica have a stronger antibiotic activity compared to other extracts. In comparison to tetracycline, the antibiotic activity of above extracts can be determined as a poor. The aqueous-ethanol extracts (60% ethanol) showed a stronger antioxidative activity compared to other extracts. In comparison to chlorogenic acid the antioxidative activity of above extracts is poor. There was found no difference in antibiotic and antioxidative activity between extracts obtained from hydroponic and field cultivation. On the other hand, it was found that aqueous-ethanol extract from the herb of Centella asiatica shows the bacteriostatic activity to all Gram-positive and Gram-negative bacteria isolated from wounds of different etiology (MIC, 10–40 mg/ml). This extract did not show any irritative and mutagenic activity according to OECD directives. The mentioned extract applied topically in form of 1% cream showed tendency to reduce oedema induced by carrageen after 3 h from application (ca. 12%). We conclude that the topically applied preparation (cream or gel) containing 5% of investigated aqueous extract from herb of Centella asiatica (50 mg/g of preparation) can be used for healing of infected wounds in hospitalized patients.
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