Preliminary pharmacological investigations of biotransformed roseroot (Rhodiola rosea L.) callus tissue
Abstract
Callus tissues from Rhodiola rosea L., a plant popular in traditional Russian and Asian medicine,
treated with biosynthesis precursors of salidroside (p-tyrosol) and rosavins (cinnamic alcohol),
were tested on the animals for the pharmacological activities of the extracts. Authors
investigated the behavioural activity using locomotor activity and the motor coordination
test. A single administration of extract from the callus tissue non treated with precursors resulted
in stimulant effects on rats. The extract enriched in rosavins (after biotransformation)
showed the inhibition of activity of tested animals. The more detailed studies concerning the
exact nature of the effects especially after chronic administration are needed.
Key words: Rhodiola rosea L., biotransformation, callus cultures, Compact Callus Aggregate (CCA),