Preliminary pharmacological investigations of biotransformed roseroot (Rhodiola rosea L.) callus tissue

ANNA KRAJEWSKA-PATAN, MARIOLA DREGER, ANNA ŁOWICKA, MAŁGORZATA GÓRSKA-PAUKSZTA, ALINA MŚCISZ, PRZEMYSŁAW Ł. MIKOŁAJCZAK, WALDEMAR BUCHWALD, MIROSŁAWA FURMANOWA, PRZEMYSŁAW M. MROZIKIEWICZ

Abstract

Callus tissues from Rhodiola rosea L., a plant popular in traditional Russian and Asian medicine, treated with biosynthesis precursors of salidroside (p-tyrosol) and rosavins (cinnamic alcohol), were tested on the animals for the pharmacological activities of the extracts. Authors investigated the behavioural activity using locomotor activity and the motor coordination test. A single administration of extract from the callus tissue non treated with precursors resulted in stimulant effects on rats. The extract enriched in rosavins (after biotransformation) showed the inhibition of activity of tested animals. The more detailed studies concerning the exact nature of the effects especially after chronic administration are needed. Key words: Rhodiola rosea L., biotransformation, callus cultures, Compact Callus Aggregate (CCA),
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