Molecular mechanisms of regulation of CYP enzymes of phase I metabolism of xenobiotics – synthetic drugs and herbal preparations

ANNA BOGACZ, MONIKA KARASIEWICZ, RADOSŁAW KUJAWSKI, JOANNA BARTKOWIAK-WIECZOREK, JOANNA CICHOCKA, ALEKSANDRA KOWALSKA, BOGUSŁAW CZERNY, KAROLINA RUDZIŃSKA, EDMUND GRZEŚKOWIAK, PRZEMYSŁAW M. MROZIKIEWICZ

Abstract

The understanding of the pharmacokinetic properties of synthetic drugs as well as herbal preparations used in treatment of many diseases offers a real opportunity to eliminate or minimize the interaction between the active substances. This is of particular clinical importance because it can decrease or increase the action of drugs what is the major cause of failure of pharmacotherapy. Understanding the molecular basis of interaction of substances with enzymes of drug metabolism is extremely helpful in treatment planning and its practical application. The experimental and clinical studies aimed to complete the characterization of the mechanisms of many factors that modulate the activity of cytochrome P450 enzymes, can provide a lot of evidence guaranteeing the safety of herbal products.
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